BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Graduate School EPS - ECPv6.16.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Graduate School EPS
X-ORIGINAL-URL:https://graduateschool-eps.info
X-WR-CALDESC:Events for Graduate School EPS
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Amsterdam
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20270328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20271031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Amsterdam:20260420T140000
DTEND;TZID=Europe/Amsterdam:20260420T170000
DTSTAMP:20260708T201923
CREATED:20251222T105451Z
LAST-MODIFIED:20260604T232319Z
UID:5262-1776693600-1776704400@graduateschool-eps.info
SUMMARY:Workshop: Biosynthesis of Natural Products – From Genes to Molecules to Data
DESCRIPTION:Date: 20 April 2026 (14:00–17:00 + borrel afterwards)\nLocation: Room B9210+B9211\,  Aurora building nr. 127\, Wageningen Campus\nInstructors:  Joelle Mergola Greef (LU) · Barbara Terlouw (WUR) · Esteban Charria Girón (WUR)\nAudience: Wageningen University & Research / Affiliated institutes (max. 50 participants)\nRegistration: open (deadline 13 April)\nContact: Esteban Charria Girón (esteban.charriagiron@wur.nl) \nLearning goals\nBy the end of the workshop\, participants will: \n\nRecognize the core logic of assembly-line biosynthesis for polyketide\, nonribosomal peptide\, RiPP\, terpene\, and hybrids.\nInterpret basic biosynthetic gene cluster (BGC) architectures and infer likely building blocks and tailoring steps.\nFormulate simple experimental set ups to test biosynthetic hypotheses.\nIdentify bioinformatics tools for natural products discovery available at BIF (e.g. genome mining\, biosynthesis-informed fingerprints\, knowledge graphs).\n\nProgram (14:00–17:00)\n14:00–14:10 – Welcome & framing: “From genes to molecules to data”: Short welcome\, practical information\, and introductions of the three instructors. Brief audience poll (wet-lab vs computational vs both)\, workshop expectations\, and an overview of the storyline: from biosynthetic gene clusters to molecules\, data & AI\, and back. \n14:10–14:30 – Lightning pitches: Selected lightning talks from participants (5 talks x 4 min each). Each pitch briefly answers: \n\nWhat are you working on?\nHow does natural products biosynthesis play a role in your work?\nOne concrete question or challenge you have (one slide).\n\n14:30–15:30 – Three perspectives\, one pipeline \n1) Chemical logic of biosynthesis: Going over the building blocks and substrates employed in different pathways (acetyl/malonyl units\, amino acids\, isoprene units\, shikimate-derived intermediates\, etc.). Typical reactions in natural product biosynthesis: C–C and C–N bond formation\, redox chemistry\, and tailoring reactions. Also explain how the “same” chemistry is wired differently in Bacteria\, fungi\, and plants. \n2) Experimental hooks & what we actually see: How can we translate biosynthetic insights into real experiments: \n\nScreening and untargeted metabolomics (What is there?).\nWhat you expect to see in LC-MS/MS experiments for a PKS vs NRPS product.\nTypical follow-up experiments: feeding experiments\, co-culture\, mutants\, overexpression.\nHeterologous expression of target BGCs and what can go wrong (e.g. shunt products or side pathways in host).\n\n3) Anecdotes of NP discoveries – From bioinformatics to experimental data and back: How genome mining tools identify signatures of the chemistry just discussed (domain architectures\, motifs\, “biosynthetic fingerprints”) and how ML/fingerprints/knowledge graphs\, together with core reference databases (e.g. MIBiG\, MITE\, NPAtlas\, and others)\, can support discovery – illustrated via concrete stories: \n\nHow genome mining + pathway logic guided biosynthetic pathway elucidation for tridecaptin and marushamycin.\nCollaborative biosynthesis / oligomerization\, showing how BGC predictions\, MS/MS data and context-dependent expression come together.\nNocardichelin biosynthesis and lipopeptide discovery guided by Harvest.\n\n15:20–15:35 – Mini panel Q&A: Joint Q&A with all three instructors \n15:35–15:45 – Coffee / tea break \n15:45–16:45 – Rotating mini-workshops (3 stations): Participants are divided into three groups (A\, B\, C). Each group visits all three stations in rotation (~20 minutes per station\, plus short changeovers). \nStation 1 — Reading BGCs like a map: Participants work with printed BGC cartoons (PKS\, NRPS\, hybrid) and: \n\nIdentify the biosynthetic class and building blocks.\nDiscuss the roles of key tailoring enzymes.\n\nStation 2 — From phenotype to molecules: Using a case study (e.g. antibiotic discovery)\, groups see figures (inhibition data or FERMO output) and: \n\nPropose what biosynthetic class might be involved (based on MS/MS and BGC results).\nSuggest follow-up experiments to test their hypotheses.\n\nStation 3 — Tools & AI: Demo or screenshots of BGC-to-compound prediction (RetroMol and Harvest)\, biosynthesis-informed fingerprints and knowledge graph concepts. Short exercise in which participants discuss how two example molecules might be represented and connected in such a system. \n16:45–17:00 – Wrap-up: Final recap of key messages and practical information about slides/materials\, tools\, and any mailing list or follow-up activities. \nBorrel & networking (from 17:00)\nInformal borrel after the workshop\, offering time for networking and follow-up discussions. Participants are encouraged to connect across groups and disciplines\, and to explore potential collaborations within the WUR and friends ecosystem. \nFee\nThe fee for this workshop for all participants is € 50\,- \nCancellation\nYou may cancel free of charge up to two weeks before the start of the course. After this date you will be charged the participation fee. In case of a no-show you will be charged the participation fee with an added € 50\,- cancellation fee. \nRegistration
URL:https://graduateschool-eps.info/event/workshop-biosynthesis-of-natural-products-from-genes-to-molecules-to-data/
LOCATION:Aurora building\, Wageningen Campus\, Vijfde Polder 1\, Wageningen\, 6708 WC
CATEGORIES:EPS courses,Recurring events incidental
ORGANIZER;CN="WUR Bioinformatics":MAILTO:esteban.charriagiron@wur.nl
END:VEVENT
END:VCALENDAR